FATTY ACID-SENSITIVE ACID PHOSPHATASE ACTIVITY OF TUBERCLE BACILLI
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چکیده
منابع مشابه
Pyruvic acid egg medium for tubercle bacilli.
Sputum culture for tubercle bacilli on a solid egg medium containing glycerol was compared with culture on a similar medium containing pyruvic acid and no glycerol. Tubercle bacilli from the sputum of five out of 99 patients grew on pyruvic acid medium but not on glycerol medium. The addition of pyruvic acid is therefore essential when an egg medium is used for the cultural diagnosis of tubercu...
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The activity of different analogs of pyrazinamide on Mycobacterium tuberculosis fatty acid synthase type I (FASI) in replicating bacilli was studied. Palmitic acid biosynthesis was diminished by 96% in bacilli treated with n-propyl pyrazinoate, 94% in bacilli treated with 5-chloro-pyrazinamide, and 97% in bacilli treated with pyrazinoic acid, the pharmacologically active agent of pyrazinamide. ...
متن کاملImproved sensitivity of direct microscopy for acid-fast bacilli: sedimentation as an alternative to centrifugation for concentration of tubercle bacilli.
There is a great need for improved methods for the diagnosis of tuberculosis by techniques that are appropriate for control programs in low-income countries. Liquefaction of sputum with sodium hypochlorite followed by concentration of bacilli through overnight sedimentation significantly increases the sensitivity of direct microscopy, and this method could be an alternative for diagnostic cente...
متن کاملBactericidal action of oleic acid for tubercle bacilli. II. Morphological response.
In the previous report (Minami, 1957), the bactericidal action of oleic acid on tubercle bacilli was studied, and it was concluded that some particular portion of the cell's surface structure was concerned with this action. In the present paper, the electron microscopic studies were carried out to look for a morphological base for the bactericidal action of oleic and other homologous fatty acid...
متن کاملComparison of solid and liquid medium sensitivity tests of tubercle bacilli to para-aminosalicylic acid.
In the treatment of tuberculosis para-aminosalicylic acid (P.A.S.) is now chiefly used in combination with streptomycin or isoniazid with the aim of preventing or delaying the emergence of drug-resistant strains of tubercle bacilli (Medical Research Council, 1950, 1953c). Such combined therapy is only effective in preventing drug resistance when the strains obtained before the start of treatmen...
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ژورنال
عنوان ژورنال: Japanese Journal of Medical Science and Biology
سال: 1992
ISSN: 0021-5112,1884-2828
DOI: 10.7883/yoken1952.45.19